Investment Q&A

• State Street SPDR S&P Biotech ETF (XBI $116.65)
  • $116.65 P/E (TTM): 18.21X Cap: $7.39B
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Q: What do you think of XBI here? It seems to have broken out. When biotech runs, it tends to run hard.

Upvote 2

Read Answer Asked by Michael on November 03, 2025

• Home Depot Inc. (The) (HD $343.32)
  • $343.32 P/E (TTM): 22.74X Cap: $341.73B
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• Nike Inc. (NKE $62.80)
  • $62.80 P/E (TTM): 32.12X Cap: $90.80B
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• United Airlines Holdings Inc. (UAL $92.20)
  • $92.20 P/E (TTM): 9.13X Cap: $29.15B
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• Suncor Energy Inc. (SU $62.43)
  • $62.43 P/E (TTM): 14.34X Cap: $75.66B
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• Canadian Natural Resources Limited (CNQ $47.11)
  • $47.11 P/E (TTM): 15.08X Cap: $99.78B
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• Cenovus Energy Inc. (CVE $25.20)
  • $25.20 P/E (TTM): 14.93X Cap: $45.64B
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• Air Canada Voting and Variable Voting Shares (AC $18.24)
  • $18.24 Cap: $5.31B
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• Teck Resources Limited Class B Subordinate Voting Shares (TECK.B $56.20)
  • $56.20 P/E (TTM): 22.65X Cap: $27.60B
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• Secure Waste Infrastructure Corp. (SES $18.24)
  • $18.24 P/E (TTM): 41.34X Cap: $3.94B
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• Capstone Copper Corp. (CS $10.98)
  • $10.98 P/E (TTM): 19.1X Cap: $8.38B
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• State Street SPDR S&P Biotech ETF (XBI $116.65)
  • $116.65 P/E (TTM): 18.21X Cap: $7.39B
  • View XBI Profile
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• Crocs Inc. (CROX $81.44)
  • $81.44 P/E (TTM): 25.57X Cap: $4.22B
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• Deckers Outdoor Corporation (DECK $85.13)
  • $85.13 P/E (TTM): 12.09X Cap: $12.40B
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• Stellantis N.V. (STLA $9.87)
  • $9.87 Cap: $28.43B
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Q: Sell or not, and proxy for sales in your opinion.
AC, TECK.B, CS, SES, STLA, ARE, CVE.
XBI-N, HD-N, NIKE-N,

Upvote 4

Read Answer Asked by Nizar on April 30, 2025

• iShares Global Healthcare Index ETF (CAD-Hedged) (XHC $71.04)
  • $71.04 P/E (TTM): 26.66X Cap: $557M
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• iShares U.S. Medical Devices ETF (IHI $62.70)
  • $62.70 P/E (TTM): 27.61X Cap: $4.21B
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• State Street SPDR S&P Biotech ETF (XBI $116.65)
  • $116.65 P/E (TTM): 18.21X Cap: $7.39B
  • View XBI Profile
  • View Questions on XBI

Q: Greetings…I’ve taken a 10% haircut on this ETF held for healthcare exposure. I could book the loss, but if I replace with another healthcare ETF inside of 30 days in your experience does the CRA have a problem with that? Also, some of the other ETF’s on the TSX look like they have fared even worse. Any ideas? (Trying to avoid holding one or two US companies individually)

Upvote 1

Read Answer Asked by Stephen R. on April 23, 2025

• iShares Biotechnology ETF (IBB $167.52)
  • $167.52 P/E (TTM): 22.53X Cap: $7.60B
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• State Street SPDR S&P Biotech ETF (XBI $116.65)
  • $116.65 P/E (TTM): 18.21X Cap: $7.39B
  • View XBI Profile
  • View Questions on XBI
• Natera Inc. (NTRA $230.63)
  • $230.63 Cap: $31.83B
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• ARK Genomic Revolution ETF (ARKG $29.02)
  • $29.02 P/E (TTM): 22.33X Cap: $1.41B
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• Catalyst Pharmaceuticals Inc. (CPRX $23.28)
  • $23.28 P/E (TTM): 13.09X Cap: $2.86B
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Q: It looks like biotech stocks are on a tear, especially those that may benefit from AI. Do you have any names that you might recommend? I'm considering the Arkg fund but I don't quite trust Cathy Woods after losing money on the Arkk fund in 2021. Thank you,

Jason

Upvote 6

Read Answer Asked by Jason on February 18, 2025

• Biogen Inc. (BIIB $175.30)
  • $175.30 P/E (TTM): 15.32X Cap: $25.71B
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• Gilead Sciences Inc. (GILD $126.64)
  • $126.64 P/E (TTM): 19.83X Cap: $155.07B
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• Illumina Inc. (ILMN $123.85)
  • $123.85 P/E (TTM): 27.48X Cap: $18.92B
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• AbbVie Inc. (ABBV $236.28)
  • $236.28 P/E (TTM): 109.78X Cap: $417.59B
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• Abbott Laboratories (ABT $128.11)
  • $128.11 P/E (TTM): 15.55X Cap: $222.76B
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• Eli Lilly and Company (LLY $1,059.70)
  • $1,059.70 P/E (TTM): 51.35X Cap: $986.30B
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• Novo Nordisk A/S (NVO $47.63)
  • $47.63 P/E (TTM): 13.96X Cap: $363.68B
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• iShares Biotechnology ETF (IBB $167.52)
  • $167.52 P/E (TTM): 22.53X Cap: $7.60B
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• State Street SPDR S&P Biotech ETF (XBI $116.65)
  • $116.65 P/E (TTM): 18.21X Cap: $7.39B
  • View XBI Profile
  • View Questions on XBI
• First Trust NYSE Arca Biotechnology ETF (FBT $35.15)
  • $35.15 P/E (TTM): 24.04X Cap: $2M
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Q: Hi 5i, can you give me the names of 4 or 5 large cap pharmaceutical companies that are buyable now. Also I'm looking for 4 or 5 Biotech companies with one drug in the market making money and maybe something in the pipeline that looks like it has a good future? for example TGTX.

Upvote 5

Read Answer Asked by Mark on January 09, 2025

• Amgen Inc. (AMGN $337.54)
  • $337.54 P/E (TTM): 26.44X Cap: $179.68B
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• Regeneron Pharmaceuticals Inc. (REGN $755.90)
  • $755.90 P/E (TTM): 16.8X Cap: $79.44B
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• Vertex Pharmaceuticals Incorporated (VRTX $426.76)
  • $426.76 P/E (TTM): 29.84X Cap: $108.27B
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• Exact Sciences Corporation (EXAS $100.90)
  • $100.90 Cap: $19.11B
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• iShares Biotechnology ETF (IBB $167.52)
  • $167.52 P/E (TTM): 22.53X Cap: $7.60B
  • View IBB Profile
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• State Street SPDR S&P Biotech ETF (XBI $116.65)
  • $116.65 P/E (TTM): 18.21X Cap: $7.39B
  • View XBI Profile
  • View Questions on XBI

Q: Hello 5i,

Wondering if you have any recommendations in the Biometrics category, either ETF or stock? And any particular thoughts regarding current valuations and future prospects versus other opportunities?

Thanks for your feedback.

Ralph

Upvote 1

Read Answer Asked by ralph on September 09, 2024

• Duke Energy Corporation (Holding Company) (DUK $122.80)
  • $122.80 P/E (TTM): 19.3X Cap: $95.29B
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• NextEra Energy Inc. (NEE $83.48)
  • $83.48 P/E (TTM): 26.84X Cap: $173.85B
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• Xylem Inc. New (XYL $140.39)
  • $140.39 P/E (TTM): 35.82X Cap: $33.60B
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• Agnico Eagle Mines Limited (AEM $225.52)
  • $225.52 P/E (TTM): 28.82X Cap: $112.45B
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• American Water Works Company Inc. (AWK $132.74)
  • $132.74 P/E (TTM): 22.34X Cap: $25B
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• iShares Biotechnology ETF (IBB $167.52)
  • $167.52 P/E (TTM): 22.53X Cap: $7.60B
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• Invesco Water Resources ETF (PHO $70.84)
  • $70.84 P/E (TTM): 28.95X Cap: $2.11B
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• State Street SPDR S&P Biotech ETF (XBI $116.65)
  • $116.65 P/E (TTM): 18.21X Cap: $7.39B
  • View XBI Profile
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• Cameco Corporation (CCJ $79.44)
  • $79.44 P/E (TTM): 95.57X Cap: $34.58B
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• Invesco S&P Global Water Index ETF (CGW $62.98)
  • $62.98 P/E (TTM): 30.72X Cap: $979M
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• First Trust Water ETF (FIW $109.32)
  • $109.32 P/E (TTM): 27.7X Cap: $1.90B
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• Karora Resources Inc. (KRR $6.70)
  • $6.70 P/E (TTM): 85.51X Cap: $1.19B
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Q: Aside from AI what industries do you think will do well over the next year, both CDA and USA? Can you pls recommend specific stocks or ETFs in those industries?

Upvote 24

Read Answer Asked by Ron on May 23, 2024

• State Street SPDR S&P Biotech ETF (XBI $116.65)
  • $116.65 P/E (TTM): 18.21X Cap: $7.39B
  • View XBI Profile
  • View Questions on XBI
• argenx SE (ARGX $918.92)
  • $918.92 Cap: $55.78B
  • View ARGX Profile
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Q: What are your thoughts on the portfolio diversification and growth potential of these securities? Thx!

Upvote 1

Read Answer Asked by David on March 06, 2024

• State Street SPDR S&P Biotech ETF (XBI $116.65)
  • $116.65 P/E (TTM): 18.21X Cap: $7.39B
  • View XBI Profile
  • View Questions on XBI

Q: Hi 5i, Is it a good time to invest in a biotech ETF such as XBI? 5 to 10 year hold. Would you wait for the markets to stabilize?

Thanks

Upvote 0

Read Answer Asked by Donald on June 06, 2022

• Stryker Corporation (SYK $368.27)
  • $368.27 P/E (TTM): 47.86X Cap: $137.85B
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• iShares Global Healthcare Index ETF (CAD-Hedged) (XHC $71.04)
  • $71.04 P/E (TTM): 26.66X Cap: $557M
  • View XHC Profile
  • View Questions on XHC
• State Street SPDR S&P Biotech ETF (XBI $116.65)
  • $116.65 P/E (TTM): 18.21X Cap: $7.39B
  • View XBI Profile
  • View Questions on XBI
• WELL Health Technologies Corp. (WELL $3.91)
  • $3.91 Cap: $972M
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• Andlauer Healthcare Group Inc. Subordinate Voting Shares (AND $54.97)
  • $54.97 P/E (TTM): 31.81X Cap: $2.14B
  • View AND Profile
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Q: Two part question, deduct as many points as you like.

I'm just wondering if anyone at 5I has glanced at the 195 page(!!) short report that Spruce Point put out last week on Stryker. Anything in particular to be concerned about? I own it in my RRSP, and have been slowly adding to my position. It is the only stock that I own in the health care sector.

Also, what would be your top pick, CA or US in this sector, if I wanted to diversify my portfolio?

Thank you for all that you do.

Upvote 0

Read Answer Asked by Ed on April 12, 2022

• State Street SPDR S&P Biotech ETF (XBI $116.65)
  • $116.65 P/E (TTM): 18.21X Cap: $7.39B
  • View XBI Profile
  • View Questions on XBI

Q: I think this bio tech etc has recently had a tough time. I know that you recommend it. But,I was wondering whether you think this might be it's time to recuperate it's losses? Do you have something that you like more than this. If so, why? As always thanks for the great service

Upvote 0

Read Answer Asked by joseph on February 04, 2022

• Intuitive Surgical Inc. (ISRG $561.61)
  • $561.61 P/E (TTM): 72.95X Cap: $201.32B
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• AbbVie Inc. (ABBV $236.28)
  • $236.28 P/E (TTM): 109.78X Cap: $417.59B
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• Cummins Inc. (CMI $472.51)
  • $472.51 P/E (TTM): 24.31X Cap: $63.93B
  • View CMI Profile
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• Lockheed Martin Corporation (LMT $460.78)
  • $460.78 P/E (TTM): 26.16X Cap: $109.32B
  • View LMT Profile
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• Stryker Corporation (SYK $368.27)
  • $368.27 P/E (TTM): 47.86X Cap: $137.85B
  • View SYK Profile
  • View Questions on SYK
• Health Care Select Sector SPDR (XLV $154.61)
  • $154.61 P/E (TTM): 23.97X Cap: $39.68B
  • View XLV Profile
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• iShares U.S. Medical Devices ETF (IHI $62.70)
  • $62.70 P/E (TTM): 27.61X Cap: $4.21B
  • View IHI Profile
  • View Questions on IHI
• State Street SPDR S&P Biotech ETF (XBI $116.65)
  • $116.65 P/E (TTM): 18.21X Cap: $7.39B
  • View XBI Profile
  • View Questions on XBI
• Vanguard Industrials ETF (VIS $287.32)
  • $287.32 P/E (TTM): 23.75X Cap: $6.19B
  • View VIS Profile
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• Industrial Select Sector SPDR (XLI $149.63)
  • $149.63 P/E (TTM): 26.63X Cap: $23.38B
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• Generac Holdlings Inc. (GNRC $146.04)
  • $146.04 P/E (TTM): 26.76X Cap: $8.57B
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• Guardant Health Inc. (GH $105.42)
  • $105.42 Cap: $13.28B
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• Jacobs Solutions Inc. (J $128.77)
  • $128.77 P/E (TTM): 36.26X Cap: $15.44B
  • View J Profile
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Q: Hi group I am light on Health care + Manufacturing stocks what are your top 3 recommendations in both stocks / ETFs and why Thanks for your guidance

Upvote 0

Read Answer Asked by Terence on August 11, 2021

• Intuitive Surgical Inc. (ISRG $561.61)
  • $561.61 P/E (TTM): 72.95X Cap: $201.32B
  • View ISRG Profile
  • View Questions on ISRG
• AbbVie Inc. (ABBV $236.28)
  • $236.28 P/E (TTM): 109.78X Cap: $417.59B
  • View ABBV Profile
  • View Questions on ABBV
• iShares Biotechnology ETF (IBB $167.52)
  • $167.52 P/E (TTM): 22.53X Cap: $7.60B
  • View IBB Profile
  • View Questions on IBB
• State Street SPDR S&P Biotech ETF (XBI $116.65)
  • $116.65 P/E (TTM): 18.21X Cap: $7.39B
  • View XBI Profile
  • View Questions on XBI
• Guardant Health Inc. (GH $105.42)
  • $105.42 Cap: $13.28B
  • View GH Profile
  • View Questions on GH
• ARK Genomic Revolution ETF (ARKG $29.02)
  • $29.02 P/E (TTM): 22.33X Cap: $1.41B
  • View ARKG Profile
  • View Questions on ARKG

Q: Is this the season for owning Biotech stocks , if so, which ones do you favour ? ...
Am I just better off owning stocks, ETFs , or the spider .
I have never done well in that subsection, so I am hesitant .

Thank you

Upvote 0

Read Answer Asked by Thomas on July 21, 2021

• Intuitive Surgical Inc. (ISRG $561.61)
  • $561.61 P/E (TTM): 72.95X Cap: $201.32B
  • View ISRG Profile
  • View Questions on ISRG
• AbbVie Inc. (ABBV $236.28)
  • $236.28 P/E (TTM): 109.78X Cap: $417.59B
  • View ABBV Profile
  • View Questions on ABBV
• Gamehost Inc. (GH $11.75)
  • $11.75 P/E (TTM): 9.32X Cap: $244M
  • View GH Profile
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  • View Reports on GH
• iShares Biotechnology ETF (IBB $167.52)
  • $167.52 P/E (TTM): 22.53X Cap: $7.60B
  • View IBB Profile
  • View Questions on IBB
• State Street SPDR S&P Biotech ETF (XBI $116.65)
  • $116.65 P/E (TTM): 18.21X Cap: $7.39B
  • View XBI Profile
  • View Questions on XBI

Q: can you recommend a Canadian and Us biotech etf and stock?
thanks

Upvote 0

Read Answer Asked by Mary on June 10, 2021

• Intuitive Surgical Inc. (ISRG $561.61)
  • $561.61 P/E (TTM): 72.95X Cap: $201.32B
  • View ISRG Profile
  • View Questions on ISRG
• AbbVie Inc. (ABBV $236.28)
  • $236.28 P/E (TTM): 109.78X Cap: $417.59B
  • View ABBV Profile
  • View Questions on ABBV
• BMO Equal Weight REITs Index ETF (ZRE $21.83)
  • $21.83 P/E (TTM): 19.0X Cap: $583M
  • View ZRE Profile
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• Vanguard Real Estate Index Fund ETF (VNQ $89.57)
  • $89.57 P/E (TTM): 32.84X Cap: $34.51B
  • View VNQ Profile
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• Health Care Select Sector SPDR (XLV $154.61)
  • $154.61 P/E (TTM): 23.97X Cap: $39.68B
  • View XLV Profile
  • View Questions on XLV
• iShares U.S. Medical Devices ETF (IHI $62.70)
  • $62.70 P/E (TTM): 27.61X Cap: $4.21B
  • View IHI Profile
  • View Questions on IHI
• State Street SPDR S&P Biotech ETF (XBI $116.65)
  • $116.65 P/E (TTM): 18.21X Cap: $7.39B
  • View XBI Profile
  • View Questions on XBI
• Guardant Health Inc. (GH $105.42)
  • $105.42 Cap: $13.28B
  • View GH Profile
  • View Questions on GH
• iShares U.S. Real Estate ETF (IYR $95.07)
  • $95.07 P/E (TTM): 32.85X Cap: $3.82B
  • View IYR Profile
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Q: Hi group need more exposure to real estate and health care - could you recommend a few in each sector also a few ETF would be helpful. I have some ready cash to deploy but am a bit queasy about investing into todays market feels oversold? also India , South America are struggling with COVID what's you thoughts (leaning towards waiting until Virus is better controlled. Wait or jump in Appreciate your thoughts

Upvote 0

Read Answer Asked by Terence on April 28, 2021

• State Street SPDR S&P Biotech ETF (XBI $116.65)
  • $116.65 P/E (TTM): 18.21X Cap: $7.39B
  • View XBI Profile
  • View Questions on XBI

Q: I am interested in investing in some US ETFs. I would put these into an RRSP account. Would there be tax consequences re the CRA or IRS in doing so? I imagine that there would be tax complications if they were held in a margin account.

Upvote 0

Read Answer Asked by Catherine on April 23, 2021

• Amgen Inc. (AMGN $337.54)
  • $337.54 P/E (TTM): 26.44X Cap: $179.68B
  • View AMGN Profile
  • View Questions on AMGN
• Biogen Inc. (BIIB $175.30)
  • $175.30 P/E (TTM): 15.32X Cap: $25.71B
  • View BIIB Profile
  • View Questions on BIIB
• Regeneron Pharmaceuticals Inc. (REGN $755.90)
  • $755.90 P/E (TTM): 16.8X Cap: $79.44B
  • View REGN Profile
  • View Questions on REGN
• Merck & Company Inc. (MRK $97.76)
  • $97.76 P/E (TTM): 12.56X Cap: $242.64B
  • View MRK Profile
  • View Questions on MRK
• iShares Biotechnology ETF (IBB $167.52)
  • $167.52 P/E (TTM): 22.53X Cap: $7.60B
  • View IBB Profile
  • View Questions on IBB
• State Street SPDR S&P Biotech ETF (XBI $116.65)
  • $116.65 P/E (TTM): 18.21X Cap: $7.39B
  • View XBI Profile
  • View Questions on XBI
• Guardant Health Inc. (GH $105.42)
  • $105.42 Cap: $13.28B
  • View GH Profile
  • View Questions on GH
• ARK Genomic Revolution ETF (ARKG $29.02)
  • $29.02 P/E (TTM): 22.33X Cap: $1.41B
  • View ARKG Profile
  • View Questions on ARKG

Q: hi group I asked a question on bio tech last Wed - no response as of yet ? - please follow up. The question was do you like the sector/ and what ETFs /top 3 individual stocks do you recommend thanks

Upvote 0

Read Answer Asked by Terence on October 19, 2020

• State Street SPDR S&P Biotech ETF (XBI $116.65)
  • $116.65 P/E (TTM): 18.21X Cap: $7.39B
  • View XBI Profile
  • View Questions on XBI
• ARK Genomic Revolution ETF (ARKG $29.02)
  • $29.02 P/E (TTM): 22.33X Cap: $1.41B
  • View ARKG Profile
  • View Questions on ARKG

Q: HI 5I gang

Our question is about biotech etf"s Looking for an etf that will cover covid vacine and treatments. A couple of ideas please.
thanks as always

Ken & Cindy

Upvote 0

Read Answer Asked by cindy on August 19, 2020

• Johnson & Johnson (JNJ $203.90)
  • $203.90 P/E (TTM): 19.55X Cap: $491.06B
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• Pfizer Inc. (PFE $25.04)
  • $25.04 P/E (TTM): 13.23X Cap: $138.73B
  • View PFE Profile
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• iShares Biotechnology ETF (IBB $167.52)
  • $167.52 P/E (TTM): 22.53X Cap: $7.60B
  • View IBB Profile
  • View Questions on IBB
• State Street SPDR S&P Biotech ETF (XBI $116.65)
  • $116.65 P/E (TTM): 18.21X Cap: $7.39B
  • View XBI Profile
  • View Questions on XBI
• Vanguard Health Care ETF (VHT $287.78)
  • $287.78 P/E (TTM): 23.36X Cap: $15.60B
  • View VHT Profile
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• Moderna Inc. (MRNA $23.72)
  • $23.72 Cap: $9.26B
  • View MRNA Profile
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Q: Can you recommend a good ETF probably US based, which has companies in the forefront of corona vaccine development/demonstration, as well as corona related testing and diagnosis.

Upvote 0

Read Answer Asked by Vinod on April 06, 2020

• iShares Biotechnology ETF (IBB $167.52)
  • $167.52 P/E (TTM): 22.53X Cap: $7.60B
  • View IBB Profile
  • View Questions on IBB
• State Street SPDR S&P Biotech ETF (XBI $116.65)
  • $116.65 P/E (TTM): 18.21X Cap: $7.39B
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• ARK Genomic Revolution ETF (ARKG $29.02)
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Q: Is there a good small cap biotech ETF you would recommend ?

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Read Answer Asked by david on May 21, 2019